阿立派唑对首发精神分裂症患者事件相关电位P300的影响

摘要

目的 探讨阿立派唑对精神分裂症患者P300认知电位的影响.方法 36例使用阿立派唑和23例使用氯氮平治疗的首发精神分裂症患者,在治疗前及治疗12周后用阳性与阴性症状量表(PANSS)判定其疗效,进行事件相关电位P300测定,判定其认知功能.结果 治疗12周后,两组患者PANSS总分、阳性症状分、阴性症状分及一般精神病理症状分均明显下降,但组间比较差异无统计学意义(P>0.05); P300认知电位测定显示使用阿立派唑治疗组在治疗后P300认知电位潜伏期缩短,波幅增高,与治疗前及与氯氮平治疗组相比较差异均具有统计学意义(P<0.05).结论 阿立派唑与氯氮平对对精神分裂症的疗效相当,但阿立派唑对精神分裂症患者的认知障碍具有一定的改善作用.%Objective To study the effects of aripiprazole on the event- related potential P300 in first episode schizophrenia patients.Methods All patients with first - episode schizophrenia were divided into two groups treated with aripiprazole (n = 36) or clozapine( n = 23).Positive and negative symptom scale (PANSS) and P300 were used to evaluate the effects of drugs and cognitive function before and after 12 weeks.Results After 12 weeks treatment, some of the scores in two groups were decreased significantly, including total scores of PANSS, positive symptom, negative symptom and general psychopathology subscales, and there were no significant difference in the two groups(P ＞0.05).The amplitude and the latency of waves P300 were shorter and higher than before treatment in aripiprazole group, and there were significant diference in the two groups (P ＜0.05).Conclusion The effects of aripiprazole and clozapine for schizophrenia are equal.Afipiprazole can improve the cognitive disorder in schizophrenia.