Objective To investigate the relationship between the mRNA expression of ER-CC1, TS, β- tubulin, UGT1A1 and the sensitivity of chemotherapy in gastric cancer patients. Methods A total of 120 gastric cancer patients were randomly divided into two groups. The control group received FOLFOX4, FOLFIRI or DCF. The mRNA expressions of the patients of experiment group were detected at first. Then the above chemotherapy regimen was administered according to the detection results. The response rate and quality of life of the two groups was observed respectively. Results The response rate and the improvement rate of quality of life in the experiment group were higher than those in the control group (P<0.05). Conclusion The mRNA expression of ERCC1, TS, β- tubulin, UGT1A1 is sensitive in the treatment of gastric cancer patients.%目的 探索切除修复交叉互补基因1(ERCC1)、胸苷酸合成酶(TS)、β-微管蛋白和尿苷二磷酸葡萄糖醛酸转移酶1A1(UGT1A1)检测的对于胃癌化疗敏感性的关系.方法 将120例进展期或术后复发的胃癌患者随机分为2组,对照组采用FOLFOX4方案、FOLFIRI方案或者DCF方案,试验组进行基因 mRNA表达水平检测,并根据检测结果针对性地选择上述3种方案.观察2组患者的近期疗效和生活质量.结果 2组患者均接受2个周期以上的化疗.试验组有效率及生活质量改善率均显著高于对照组(P＜0.05).结论 ERCC1、TS、β-微管蛋白和UGT1A1的表达水平对于晚期胃癌化疗敏感性的预测有着重要的意义,值得临床进一步研究.
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