血清C反应蛋白、铁蛋白与糖尿病视网膜病变严重程度关系的研究

摘要

目的 探讨血清C反应蛋白(CRP)、血清铁蛋白(SF)水平和糖尿病视网膜病变(DR)严重程度的关系.方法 随机选取住院的2型糖尿病患者60例,根据眼底检查结果分为无糖尿病视网膜病变组(NDR)21例、非增值期糖尿病视网膜病变组(NPDR)20例、增值期糖尿病视网膜病变组(PDR)19例.比较3组患者CRP、SF水平的关系.结果 CRP、SF水平在NDR组、NPDR组、PDR组中逐渐升高,3者间比较差异有统计学意义(P＜0 05).多因素有序logistic回归分析显示CRP SF是DR严重程度的独立危险因素.结论 血清CRP、SF水平和DR严重程度密切相关,应重视早期监测血清CRP和SF.%Objective To investigate serum C-reactive protein, serum ferritin and its relationship with the severity of diabetic retinopathy. Methods According to the fundus examination, hospitalized patients with type 2 diabetes were randomly chosen and divided into three groups, including no diabetic retinopathy group (NDR group, n =21), non-proliferative diabetic retinopathy group (NPDR group, n =20) and proliferative diabetic ertinopathy group (PDR group, n = 19). The differences in the level of C-reactive protein and serum ferritin were analyzed. Results Total C -reactive protein, serum ferritin in NDR group, NPDR group and PDR group gradually increased, and the differences among three groups were statistically significant (P<0. 05). Logistic multivari-ate regression analysis showed that C-reactive protein and serum ferritin were independent risk factors of diabetic retinopathy. Conclusion The levels of C-reactive protein and serum ferritin which have some certain relationship with the severity of diabetic retinopathy should be monitored as early as possible.