抗凝血酶Ⅲ、血浆蛋白C、纤维蛋白原与进展型卒中的相关性分析

摘要

目的 探讨抗凝血酶Ⅲ(AT-Ⅲ)、血浆蛋白C(PC)及纤维蛋白原(Fbg)与进展型卒中的关系.方法 72例急性脑梗死患者(发病24 h内),入院第2天即测定AT-Ⅲ、PC活性水平及Fbg含量,根据病程演变,分为进展组(26例)和非进展组(46例).另将同期住院的非脑血管病患者50例纳入对照组.比较各组AT-Ⅲ、PC活性水平及Fbg含量的差异.结果 3组AT-Ⅲ、PC活性水平之间比较,差异无统计学意义；进展组Fbg含量显著高于非进展组及对照组,而非进展组与对照组之间差异无统计学意义.结论 急性脑梗死患者血清Fbg水平升高与卒中进展相关,是缺血性卒中进展的有效预测指标.对该类患者提早进行干预,对降低缺血性卒中进展的发生有重要意义.%Objective To explore the relationships between antithrombin Ⅲ (AT-Ⅲ),protein C (PC),fibrinogen (Fbg) and progressive stroke.Methods Seventy-two patients with acute cerebral infarction (within 24 hours) were detected in terms of the levels of AT-Ⅲ and PC activity as well as Fbg content.The two groups were divided into progressive stroke group (n =26) and non-progressive stroke group (n =46) according to the progression of symptoms.Another 50 patients with cerebrovascular disease in the same period were selected as control group.The levels of AT-Ⅲ and PC activity as well as Fbg content in three groups were compared.Results The levels of AT-Ⅲ and PC activity in three groups showed no significant differences.Fbg content in progressive stroke group was obviously higher than that in non-progressive stroke group and the control group,while there was no significant difference between non-progressive stroke group and the control group.Conclusion Elevated Fbg in patients with acute cerebral infarction is associated with stroke progression,and is an effective predictor of progressive ischemic stroke.Early intervention for these patients is of great importance to reduce the occurrence of progressive ischemic stroke.