急性冠脉综合征患者血清抵抗素和超敏C反应蛋白水平及临床意义

摘要

Objective To investigate the levels of serum resistin and hypersensitive c-reac-tive protein (hs-CPR)in patients with acute coronary syndrome (ACS).Methods 70 patients with ACS were selected as ACS group and subdivided into unstable angina pectoris (UAP)group,st-segment elevation myocardial infarction (STEMI)group and non st-segment elevation myocardial infarction (NSTEMI)group.35 people with health examination were selected as control group. Levels of serum resistin and hr-CPR were observed at 1,3,7,14 days after chest pain occurred. Results Levels of serum resistin and hs-CPR in ACS group at different time (1,3,7,14 days af-ter chest pain occurred)were significantly higher than those in control group (P <0.05)and peaked at 3 days.There was a positive correlation between levels of serum resistin and hr-CPR (P<0.01).3 days after chest pain occurred,the level of serum resistin in STEMI group and NSTE-MI group was significantly than that in UAP group (P <0.05).Conclusion Serum resistin and hs-CPR play a significant role in development and progress of ACS.%目的：探讨急性冠脉综合征（ACS）患者血清抵抗素和超敏 C 反应蛋白（hs-CRP）水平的动态变化及临床意义。方法 ACS 患者70例根据发病类型细分为不稳定型心绞痛组（UAP 组，25例）、急性 ST 段抬高型心肌梗死组（STEMI 组，25例）和急性非 ST 段抬高型心肌梗死组（NSTEMI 组，20例），同时选取35例健康体检人员为对照组。分别检测对照组和 ACS 组患者胸痛发作后1、3、7、14 d 的血清抵抗素和 hs-CRP 水平。结果不同时间点下 ACS 组患者血清抵抗素与 hs-CRP 水平均显著高于对照组（P ＜0．05），且血清抵抗素与 hs-CRP 水平在3 d 达到最大值；ACS 组患者血清抵抗素水平与 hs-CRP 水平呈正相关（P ＜0．01）；胸痛发作3 d 时，STEMI 组、NSTEMI 组患者血清抵抗素水平均显著高于 UAP 组（P ＜0．05）。结论血清抵抗素与 hs-CRP 共同参与了 ACS 的发生发展，二者水平变化可能与 ACS 病情严重程度相关。