急性冠脉综合征患者血浆胱抑素C和超敏C反应蛋白检测的临床意义

摘要

Objective To explore the significance of cysiatin C (CysC ) and high sensitivity C-reactive protein (hs-CRP) in acute coronaiy syndrom e(ACS). M ethods 108 ACS patients, including 52 cases with acute m yocardial infarction (AM I, AM I group) and 56 cases w ith unstable angina(U A , U A group) , 54 stable angina(SA ) patients(SA group) and 52 healthy controls (control group) w ere enrolled and detected for plasm a levels of CysC and hs-CRP by latex enhanced in m unoturbidm etric ,and plasm a creatinine and urea nitrogen levels w ere also detected .Results Plasm a CysC levels in A M I group , U A group and SA group w ere significantly higher than in control group , but glorn erular filtration rate(GFR) was bwer(P<0 .01) . Plasm a CysC and hs-CRP levels in AM I group and U A group w ere significantly higher than in SA group and control group , and those in patents w ith m ulti-vessel disease were significantly higher than in patientswith single-vessel disease(P<0 .01) . Plasma level of CysC was linearly correlated with hs-CRP(r=0 .77 ,P<0 .01) .Conclusion PlasmaCysC could early reflect the changes of renal function in patientswith ACS , and could be an in portant index to reflect the inflamm ation of ACS , jistas hs-CRP .%目的 探讨检测急性冠脉综合征(ACS)患者血浆胱抑素C(CysC)和超敏C反应蛋白(hs-CRP)水平的临床意义.方法 选择108例ACS患者[急性心肌梗死(AMI)52例(AMI组),不稳定性心绞痛(UA)56例(UA组)]和54例稳定性心绞痛(SA)患者(SA组)及52例健康体检者(对照组),用乳胶增强免疫透射比浊法检测血浆CysC和hs-CRP,同时检测血清肌酐、血尿素氮等.结果 AMI组、UA组、SA组血浆CysC水平均高于对照组,肾小球滤过率(GFR)均低于对照组,AMI组、UA组血浆CysC 、hs-CRP水平均高于SA组和对照组,多支病变组血浆CysC、hs-CRP水平明显高于单支病变组(P<0.01),CysC与hs-CRP呈直线正相关(r=0.77,P<0.01).结论 血浆CysC水平能早期反映ACS患者肾功能改变,与血浆hs-CRP水平一样是反映ACS炎症程度的重要指标.