维持性血液透析患者认知功能障碍及相关危险因素分析

摘要

Objective To explore the related risk factors of cognitive dysfunction in patients with maintenance hemodialysis (MHD).Methods The cognitive dysfunction in MHD patients was evaluated by the Montreal Cognitive Assessment (MoCA),and the clinical parameters were com-pared between the non-cognitive dysfunction group and cognitive dysfunction group.Results A-mong 76 MHD patients,the number of patients with MoCA<26 was 47,and the rate of cognitive dysfunction was 61.84%.There were significant differences of the gender,age,years of education, Kt /v and the presence of diabetes,history of stroke between the two groups(P <0.05).Multiple regression analysis showed that age,years of education and stroke history were considered as the in-dependent risk factors of cognitive dysfunction in MHD patients (P <0.05).Conclusion There is a high incidence rate of cognitive dysfunction in MHD patients,and the age,years of education and stroke history are the independent risk factors of cognitive dysfunction.%目的：探讨维持性血液透析（MHD）患者认知功能障碍情况及相关危险因素。方法76例 MHD 患者根据蒙特利尔认知评估量表（MoCA）评分结果分为认知功能障碍组及非认知功能障碍组，分析其相关危险因素。结果76例 MHD 患者中47例 MoCA 得分＜26分，认知功能障碍发生率为61．84％；2组患者在性别、年龄、受教育年限、Kt /v、糖尿病及脑卒中病史方面存在显著差异（P ＜0．05）；多重逐步回归分析显示，年龄大、教育年限低及脑卒中病史为 MHD 患者发生认知功能障碍的独立危险因素（P ＜0．05）。结论认知功能障碍在维持性血液透析患者中普遍存在，年龄大、教育年限低及脑卒中病史是患者发生认知功能障碍的独立危险因素。