食管癌患者血清NGAL、Hcy、sTNF-RI、白介素及食管动力学指标的变化观察

摘要

Objective To observe and analyze the changes of serum NGAL,Hcy,sTNFRI,interleukin levels and esophageal dynamics indexes of patients with esophageal cancer.Methods A total of 66 patients with esophageal cancer in our hospital were selected as observation group,another 66 healthy persons with health examination at the same period were selected as control group,then the serum NGAL,Hcy,sTNF-RI,interleukin levels and esophageal dynamics indexes of two groups were detected and compared,and the indexes of observation group with different stages of esophageal cancer were compared.Results The serum IL-2 of observation group was lower than that of control group,serum NGAL,Hcy,sTNF-RI aud IL-6,IL-8,IL-18 levels were all higher than that of control group,and esophageal pressure,peristaltic contraction ratio and esophageal sphincter relax rate were all lower than that of control group,and the changes of those indexes of observation group with higher stage of esophageal cancer were more than that of patients with lower stage of esophageal cancer(P ＜0.05).Conclusion The serum NGAL,Hcy,sTNF-RI,interleukin levels and esophageal dynamics indexes of patients with esophageal cancer show abnormal state,and the influence of disease stages for the detection levels are great.%目的 分析食管癌患者的血清NGAL、Hcy、sTNF-RI、白介素及食管动力学指标的变化情况.方法 选取本院收治的66例食管癌患者为观察组,并选取同时间段的66名体检健康人员为对照组,然后将2组的血清NGAL、Hcy、sTNF-RI、白介素及食管动力学指标进行检测与比较,然后将观察组中不同食管癌分期者的检测指标进行比较.结果 观察组的血清IL-2低于对照组,血清NGAL、Hcy、sTNF-RI及IL-6、IL-8、ILd8则均高于对照组,另外食管收缩压、蠕动性收缩比及食管括约肌松弛率低于对照组,且观察组中食管癌分期较高者的变化大于食管癌分期较低的患者,差异均有统计学意义(P＜0.05).结论 食管癌患者的血清NGAL、Hcy、sTNF-RI、白介素及食管动力学指标呈现异常的状态,且其检测水平受疾病分期的影响较大.