目的 探讨彩色多普勒超声对孕中期孕妇双侧子宫动脉血流参数值、双侧子宫动脉舒张早期切迹的监测在子痫前期进展中的作用,并分析其与妊娠结局及新生儿预后的关系.方法 回顾性分析行孕期产前检查并分娩的89例子痫前期患者,分为轻度子痫前期组(A组),重度子痫前期组(B组),同时选择100例同期无任何妊娠合并症的单胎孕妇作为对照组(C组).比较3组孕患在孕20～26周行四维超声检查时其子宫动脉血流参数情况,测量子宫动脉的搏动指数(PI)、阻力指数(RI),记录舒张早期切迹数目,分析这些参数预测妊娠结局与新生儿预后的价值.结果 B组新生儿预后较其他2组显著较差(P＜0.05),子宫动脉PI、RI值显著高于A组及C组(P＜0.05).子痫前期组舒张早期切迹发生率显著高于对照组(P＜0.05).结论 孕中期双侧子宫动脉血流参数值及舒张早期切迹可用于预测子痫前期特别是重度子痫前期的发生.%Objective To explore indicator value of blood flow of uterine arteries in second trimester uterine artery by Doppler ultrasound and early diastolic notch in the prediction of preeclampsia development,and to analyze the relationship between these values and pregnancy outcomes and neonatal prognosis.Methods A total of 89 puerperae cases with preeclampsia underwent pregnant examinations in our hospital were retrospectively reviewed,and were divided into mild preeclampsia (group A) and severe preeclampsia (group B),and 100 women with normal singleton pregnancies were selected as control group(Group C).Four-dimensional ultrasound was adopted to detect pulsatility indices (PI),resistance indices (RI) and early-diastolic notch of bilateral uterine arteries in the three groups from 20 to 26 gestational weeks.The pulsatility index (PI) and resistance index (RI) of the uterine artery were measured,and the number of early diastolic waves was recorded.The relationship between these values and the outcomes of pregnancy and neonates was analyzed.Results Neonatal prognosis of Group B was worse than that of group A and group C (P ＜ 0.05);The uterine artery PI and RI of group B were higher than that of group A and group C (P ＜ 0.05).The early diastolic notch of group A and group B was higher than that of group C (P ＜ 0.05).Conclusion The indicator value of blood flow in uterine artery and the early diastolic notch in the second trimester could monitor the occurrence of preeclampsia,especially severe preeclampsia and they are useful to predict preeclampsia severity and prenatal prognosis.
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