炎琥宁注射液联合左氧氟沙星治疗小儿腹泻的临床效果观察

摘要

目的 探讨炎琥宁注射液联合左氧氟沙星治疗小儿腹泻的临床效果观察.方法 选取小儿感染性腹泻患儿90例,按随机数字表法分为对照组(n=45)及观察组(n=45),2组患儿均给予补液、补充热量及维持水电解质平衡等常规治疗,对照组在常规治疗的基础上给予左氧氟沙星治疗,观察组在对照组的基础上给予炎琥宁注射治疗,2组均治疗1周.观察2组患者的大便性状及大便次数恢复正常时间,比较2组患者治疗前后的腹泻次数及胃肠道症状评分,检测2组患者的血清肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、炎症因子如肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-10 (IL-10)水平的变化情况,比较2组患者的治疗有效率,观察2组患者的不良反应.结果 观察组大便性状及大便次数恢复正常时间均较对照组显著缩短(P＜0.05);2组患者治疗后腹泻次数均显著减少,且观察组腹泻次数较对照组显著减少(P＜0.05);2组患者治疗后胃肠道症状评分均改善,而观察组胃肠道症状评分显著优于对照组(P＜0.05);治疗后2组患者血清CK、CK-MB 、TNF-α及IL-6均较治疗前降低,而IL-10较治疗前升高,且观察组各血清检测指标均显著优于对照组(P＜0.05);观察组的治疗总有效率为95.56％,显著高于对照组的73.33％ (P ＜0.05).对照组有1例恶心、呕吐,无其他不良反应发生,观察组无明显不良反应,差异无统计学意义(P＞0.05).结论 炎琥宁注射液联合左氧氟沙星治疗小儿腹泻,可有效降低血清心肌酶、同工酶及炎症反应,提高临床疗效,改善临床症状,值得临床推广.%Objective To observe the clinical effect of andrographolide injection combined with levofloxacin in the treatment of infantile diarrhea.Methods A total of 90 children with infectious diarrhea admitted in our hospital were randomly divided into control group (n =45) and observation group (n =45).The patients of two groups were given fluid supplementation,heat supply and maintenance of water-electrolyte balance and other conventional treatment.The control group was additionally given levofloxacin treatment,while the observation group was additionally given andrographolide injection,the treatment was lasted for one week for two groups.The recovery time for normal stool and stool frequency were observed,and were compared,and diarrhea times and gastrointestinal symptoms score before and after treatment of two groups were compared.The changes of serum creatine kinase (CK),creatine kinase isoenzyme (CK-MB),inflammatory factor TNF-α,interleukin-6,interleukin-10 levels of the two groups were detected.Meanwhile,clinical outcomes,and the adverse reactions of the two groups were compared.Results Compared with the control group,the stool property and frequency in the observation group were shorter than that in the control group (P ＜ 0.05).Patients of two groups had reduced diarrhea after treatment,and diarrhea times in the observation group was significantly lower than that in the control group (P ＜ 0.05).After treatment,gastrointestinal symptoms of two groups were improved,and gastrointestinal symptoms score in the observation group was significantly better than that in the control group (P ＜ 0.05);After treatment,the serum levels of CK,CK-MB,TNF-α and IL-6 were lower,while IL-10 was higher than that before treatment,and the observation group showed better results than the control group (P ＜ 0.05).The effective rate of observation group was significantly higher than that in the control group (95.56％ vs.73.33％,P ＜0.05).There was 1 case with nausea and vomiting in the control group,without other adverse reactions,no adverse reactions occurred in the observation group (P ＞ 0.05).Conclusion Andrographolide injection combined with levofloxacin in the treatment of infantile diarrhea can effectively reduce the serum myocardial enzyme,isozyme and inflammatory reaction,and improve the clinical efficacy and symptoms,so it is worthy of clinical promotion.