肺结核病患者强化治疗期间肝功能的改变

摘要

目的　探讨肺结核病患者在抗结核强化治疗期的肝功能改变。方法　对131例肺结核患者强化期肝功能改变进行分析，将131例分为三组，即HBV-M阳性组54例，HBsAb阳性30例，HBV-M阴性组47例。结果　54例HBV-M阳性组肝功能异常24例(44.4%)，明显高于HBV-M阴性组(14.9%)和HBsAb阳性组(20%)；肺结核病患者肝功能的异常多发生在治疗后第1个月内。结论　在抗结核药物强化期HBV-M阳性肺结核病患者易发生肝脏损害。%Objective　To investigate the changes of hepatic function in pulmonary tuberculotic.Methods　131 treated patients with pulmonary tuberculosis were divided into 3 groups, including positive HBV-M(54 cases), positive HbsAb (30 cases) and negative HBV-M (47 cases) group.Their changes of hepatic function were analyzed at intensive stage. Results　The incidence of abnormal hepatic function in positive HBV-M group was 44.4%, being significantly higher than that in negtive HBV-M group (14.9%)and positive HbsAb group (20%).The abnormal hepatic function was mostly found after a month's therapy.Conclusion　At intensive stage of antituberculotic therapy, liver injury easily occurred in pulmonary tuberculotic patients with positive HBV-M.