冠状动脉粥样硬化性心脏病患者冠状动脉病变SYNTAX评分与高敏C反应蛋白、基质金属蛋白酶-9的关系

摘要

Objective To investigate the relationship between SYNTAX score and the levels of high sensitive C-reactive protein(hs-CRP) and matrix metalloproteinase-9 (MMP-9) in coronary heart disease.Methods 76 CHD patients were enrolled in our study,and 32 normal patients were selected as control group.The risk factors of coronary heart disease were analyzed by logistic regression method,the CHD patients were divided into three subgroups based on SYNTAX score,concluding 30 patients with low score,18 patients with high score and 28 patients between them.At last,the relationship between SYNTAX score and both hs-CRP and MMP-9 was analyzed in each group.Results LDL-C,hs-CRP,MMP-9 and the history of smoking and diabetes mellitus were risk factors of CHD,the levels of hs-CRP and MMP-9 were gradually increasing from low-score group to high-score group,both hs-CRP and MMP-9 had a positive relevance with SYNTAX score (r =0.519,0.586,P ＜ 0.01).Conclusion SYNTAX scoring is an ideal index to calculate the complexity of coronary heart disease,the higher the SYNTAX score,the higher the levels of hs-CRP and MMP-9,and the more complexity of coronary heart disease.%目的 探讨冠状动脉粥样硬化性心脏病(简称冠心病,CHD)患者冠状动脉病变SYNTAX评分与高敏C反应蛋白(hs-CRP)、基质金属蛋白酶-9(MMP-9)的关系.方法 选择经冠状动脉造影证实的冠心病患者76例和同期住院的非冠心病患者32例(对照组),通过Logistic回归分析确定冠心病的危险因素,依据SYNTAX评分结果分为低分组30例、中分组28例和高分组18例,比较SYNTAX评分与血清hs-CRP、MMP-9的关系.结果 低密度脂蛋白胆固醇、hs-CRP、MMP-9、吸烟史及糖尿病史是冠心病患者的独立危险因素;冠心病患者低分组、中分组、高分组之间,随着SYNTAX评分的增加血清hs-CRP、MMP-9水平增加,线性相关分析结果显示,血清hs-CRP、MMP-9与SYNTAX评分呈正相关(r=0.519、0.586,P＜0.01).结论 SYNTAX评分是预测冠心病患者病变程度较理想的指标,该评分越高血清炎症因子hs-CRP、MMP-9表达水平越高,患者冠状动脉病变越严重.