酒精性肝病合并肝炎病毒感染的临床特点分析

摘要

目的 探讨酒精性肝病合并肝炎病毒感染的临床特点,评价酒精性肝病与肝炎病毒感染的关系.方法 选择我院2004年1月至2011年5月收治经确诊的271例酒精性肝病患者,对其临床资料及实验室结果进行回顾性分析.结果 271例酒精性肝病中118例(43.5％)肝炎病毒标志物阳性,其中乙型肝炎病毒标志物阳性的101例(37.3％),丙型肝炎病毒标志物阳性的2例(0.7％),戊型肝炎病毒标志物阳性的14例(5.2％),甲型肝炎病毒标志物阳性的1例(0.3％),无肝炎病毒感染的153例(56.5％).肝炎病毒感染阳性组上消化道出血、肝性脑病百分率比较差异有统计学意义(P＜0.05).两组血清肝功能均有不同程度的异常,且阳性组ALT、AST、TBil、GGT明显高于阴性组,差异有统计学意义(P＜0.05).结论 酒精与肝炎病毒对肝脏损伤有协同作用,酒精性肝病合并肝炎病毒感染加重肝脏的损伤.%Objective To explore the clinical characteristics of AID cases infected with hepatitis viruses and to evaluate the relationship of ALD with hepatitis virus infection. Methods 271 ALD cases from January 2004 to May 2011 were selected. The clinical manifestations and laboratory test results were retrospectively analyzed. Results 118 of 271 ALD cases(43. 5% ) were infected with hepatitis virus, among which, HBV, HCV, HEV and HAV infection was found in 101(37.3%), 2(0.7%), 14(5.2%) and 1 (0.3%) respectively. The significant deviation was shown in incidence rate of upper gastrointestinal hemorrhage and hepatic encephalopathy between hepatitis virus infected group and non - infected group (P < 0. 05). The two groups' serum liver function were at different degree of abnormality, with ALT, AST, TBil, GGT of positive group significantly higher than the negative groups, showing significant differences (P <0. 05) . Conclusion Alcoholand hepatitis viruses play a role of synergistic action in qausing damage to liver. The liver function was more serious in ALD cases infected with hepatitis viruses.