purified monomer polypeptide multimer, vaccine composition for prophylaxis or treatment of hepatitis and mammalian virus infection, diagnostic kit for hepatitis virus infection and biological samples, in vitro diagnostic method for hepatitis virus infection and in mammals, method for in vitro detection of total antibodies against hepatitis virus and in biological samples, method for in vitro detection of igg antibody against hepatitis virus and in biological samples and method for in vitro detection of igm antibody against hepatitis virus hepatitis and in biological samples

摘要

"hepatitis e virus polypeptide fragments, vaccine composition and diagnostic kits comprising the same and use thereof". The present invention relates to the polypeptide (s) comprising the amino acid sequence set forth in hepatitis virus orphan sequence 2 and / or fragments thereof, which is in the form of a nonpolymeric polypeptide. where n is an integer from 1-180; a chimeric protein consisting of a polypeptide of the present invention and a conserved fragment of the influenza virus hemagglutin antigen; a polypeptide of the present invention linked to a polypeptide containing the hepatitis virus orf3 epitope and or an immunogenic fragment thereof; a recombinant expression vector comprising the DNA molecule encoding the above polypeptides and the host cell transformed with said recombinant expression vector which is capable of expressing the polypeptide of the present invention. The present invention further relates to a hepatitis virus vaccine composition and comprising the above-mentioned polypeptide, or hepatitis virus infection diagnostic kit and comprising the above-mentioned polypeptide, which includes igg, igm, or hepatitis virus total antibody diagnostic kit and, and for the use of the vaccine composition and diagnostic kit for prophylaxis, diagnosis and / or treatment of hepatitis virus infection e.