原发性胆汁性肝硬化的发病机制及影H向预后的危险因素研究进展

摘要

原发性胆汁性肝硬化(PBC)是一种原因不明的,自身免疫介导的,以肝内中、小胆管胆汁淤积为特征的肝病.本文就目前国内外已报道的PBC的发病机制及影响其预后的相关危险因素进行综述.%Primary biliary cirrhosis ( PBC) is a chronic cholestatic liver disease characterized by autoimmune - mediated destruction of small - and medium - sized intrahepatic bile ducts. Although many studies reported that PBC results from a combination of multiple genetic factors and superimposed environmental trigger, the precise mechanisms under the disease progression are still unknown. We summarized the patho-genesis and risk factors related to prognosis of PBC in this review.