放射治疗局部进展胰腺癌的研究进展

摘要

局部进展胰腺癌的预后较差,传统放射治疗、传统放射治疗联合化学药物治疗对局部进展胰腺的局部控制及生存获益有限.立体定向放射治疗和调强放射治疗能够控制局部肿瘤进展,改善患者生存质量,且不良反应相对较少,近年在局部进展胰腺癌中逐步应用.抑制DNA修复药物发展迅速,DNA修复抑制剂联合放射治疗在分子、细胞、动物水平经广泛研究,并已初步在临床应用,能够有效改善局部进展胰腺癌的预后.%Locally advanced pancreatic cancer has a poor prognosis,and conventional radiotherapy alone or combined with chemotherapy has limited effects on local control of locally advanced pancreatic cancer and survival benefit for such patients.Stereotactic radiotherapy and intensity-modulated radiotherapy can control local tumor progression and improve patients' quality of life with few adverse effects and have gradually been used in the treatment of locally advanced pancreatic cancer in recent years.Rapid development of drugs inhibiting DNA repair and extensive research on DNA repair inhibitors at the molecular,cellular,and animal levels and their preliminary clinical application can effectively improve the prognosis of locally advanced pancreatic cancer.