代谢综合征相关组分与结直肠绒毛状腺瘤相关性研究

摘要

Objective To explore the relationship between metabolic syndrome and the occurrence of colorectal villous adenoma. Methods A retrospective study was conducted in 56 patients with colorectal villous adenoma (experimental group) and 68 patients without abnormal findings in enteroscopy (control group) admitted to this hospital during January 2010 to January 2018. The body mass index,blood levels of glucose, triglycerides,high - density lipoprotein and cholesterol were compared between these two groups. Logistic regression analysis was used for possible risk factors associated with colorectal villous adenoma,and the relationship between metabolic syndrome and its components with colorectal villous adenoma. Results The level of triglyceride and body mass index in experimental group were all higher than those of control group (1. 9 ± 0. 8 mmol /L,24. 3 ± 3. 8 kg /m2,6. 2 ± 0. 9 mmol vs. 1. 5 ± 0. 9 mmol /L,22. 5 ± 2. 9 kg /m2,5. 6 ± 0. 8 mmol /L) with significant statistical difference (P ＜ 0. 05). Level of Triglycerides,body mass index and fasting blood level of glucose were risk factors of colorectal villous adenoma (OR = 1. 86,95％ CI: 1. 05 ～ 3. 68,P = 0. 03; OR = 2. 45,95％ CI: 1. 00 ～ 6. 04,P = 0. 04; OR = 1. 23,95％ CI: 1. 02 ～ 1. 50,P = 0. 04). Conclusion Body mass index,and blood levels of triglyceride and fasting glucose are related to the occurrence of colorectal villous adenoma. Therefore, patients with above - mentioned abnormal indicators should be screened with colonoscopy to achieve early detection and early treatment.%目的 探讨代谢综合征相关组分与结直肠绒毛状腺瘤发生的关系.方法 采用回顾性研究的方法,选取 2010年1月至2018年1月首都医科大学附属北京天坛医院收治的56例结直肠绒毛状腺瘤患者(试验组)和68例肠镜检查未发现异常者(对照组).比较两组患者的体重指数、血糖、甘油三酯、高密度脂蛋白、胆固醇水平,对可能与结直肠绒毛状腺瘤相关的危险因素采用Logistic 回归分析,分析代谢综合征相关组分与结直肠绒毛状腺瘤发生的关系.结果 试验组患者甘油三酯、体重指数及空腹血糖(1.9 ± 0.8 mmol /L,24.3 ± 3.8 kg /m2,6.2 ± 0.9 mmol /L)明显高于对照组(1.5 ± 0.9 mmol /L,22.5 ± 2.9 kg /m2,5.6 ± 0.8 mmol /L),差异均有统计学意义(P ＜ 0.05).Logistic 回归分析表明甘油三酯,体重指数及空腹血糖为结直肠绒毛状腺瘤的危险因素(OR = 1.86,95％ CI:1.05 ～ 3.68,P = 0.03;OR = 2.45,95％ CI:1.00 ～ 6.04,P = 0.04;OR = 1.23,95％CI:1.02 ～ 1.50,P = 0.04).结论 体重指数、甘油三酯及空腹血糖与结直肠绒毛状腺瘤发生相关,应注意对上述指标异常人群的结肠镜筛查,做到早期发现、早治疗.