Wnt信号通路与常染色体显性多囊肾病发病关系的研究进展

摘要

Wnt信号通路是一条保守的信号途径,其生物学效应非常广泛,对细胞的黏附、迁移、增殖和凋亡具有调控作用,与多种疾病的发生发展均有关系.近年研究发现,在常染色体显性多囊肾病的发病过程中,Wnt信号通路扮演着非常重要的角色.本文就Wnt信号通路与常染色体显性多囊肾病发病的研究进展做一综述.%Wnt signaling pathway is a conserved signaling pathway. It has wide range of biological effects on cell adhesion, migration,proliferation and regulation of apoptosis, and is related to the development of various diseases. Recent studies have found that Wnt signaling pathway plays a very important role in the pathogenesis of autosomal dominant polycystic kidney disease. In this paper,research progress of Wnt signaling pathway and the pathogenesis of autosomal dominant polycystic kidney disease are reviewed.