胸腔积液肿瘤标志物联合检测的临床意义探讨

摘要

Objective The pleural effusion of four tumor markers ( CA125, CA199, CEA, CA153 ) joint detection, To investigate the pleural effusion of four tumor markers in elevated levels were detected separately to clinical significance. Methods Selection of 52 patients with malignant pleural effusion and benign patients with pleural effusion 36 cases included in the study, the immune chemiluminescence detection all patients CA125, CEA, CA199 and CA125 level, compare the four tumor markers level and individual test results. Results Malignant pleural effusion group of pleural effusion tumor markers of CA125 and CA199, CEA, CA153 were higher than benign pleural effusion group, P < 0.01; Single tumor markers detection sensitivity less than four joint detection. Conclusion CA125 and CA199, CA153 , CEA joint detection is better than single detection, four tumor markers joint detection can obviously improve the diagnostic sensitivity, which will help for the early diagnosis of pleural effusion.%目的 通过对胸腔积液4项肿瘤标志物癌胚抗原(CEA)、癌抗原199(CA199)、癌抗原125(CA125)、癌抗原153(CA153)的联合检测,探讨对胸腔积液4项肿瘤标志物水平与单独检测的临床意义.方法 选取恶性胸腔积液52例以及良性胸腔积液患者36例纳入研究,采用免疫化学发光法检测所有患者CA125、CA125,CA199及CEA水平,比较上述4项肿瘤标志物水平与单独检测结果.结果 恶性胸腔积液肿瘤标志物CA125、CA199、CEA、CA153均高于良性胸腔积液患者,(P<0.01);单项肿瘤标志物检测的敏感度低于4项联合检测.结论 CA125、CA199、CEA、CA153的联合检测敏感度优于单项检测,4项肿瘤标志物的联合检测可明显提高诊断的敏感度,利于对胸腔积液性质的早期诊断.