Objective Toobservetheclinicaleffectofambroxolinthetreatmentofpatientswithsecretoryotitismedia,andstudyitsinflu-encefortheserumandearfluidinflammatorymediators.Methods 78patientswithsecretoryotitismediainourhospitalfromDecember2010to June 2013 were selected as research object. And 78 cases were randomly divided into control group( routine secretory otitis media treatment group) 39 cases and observation group( routine treatment and ambroxol group)39 cases. The total effective rates at first and second week after the treat-ment,serumandearfluidinflammatorymediatorsbeforeandafterthetreatmentoftwogroupswerecompared.Results Thetotaleffectiveratesof observation group at first and second week after the treatment were both higher than those of control group. Serum and ear fluid inflammatory media-tors were all lower than those of control group. There were all significant differences between those indexes of two groups after the treatment( all P<0.05).Conclusion Theclinicaleffectofambroxolinthetreatmentofpatientswithsecretoryotitismediaisbetter,anditsimprovementforthe serum and ear fluid inflammatory mediators is obvious too. Therefore,its application value for the secretory otitis media is higher.%目的：观察氨溴索治疗分泌性中耳炎的临床疗效，并探讨其对血清、耳积液炎性介质的影响。方法选取2010年12月至2013年6月进行治疗的78例分泌性中耳炎患者为研究对象。将78例患者随机分为对照组（常规分泌性中耳炎治疗组）39例和观察组（常规治疗加氨溴索组）39例。比较两组患者治疗后1周与2周的总有效率及治疗前后的血清、耳积液炎性介质水平。结果观察组患者治疗后1周与2周的总有效率分别高于对照组，治疗后的血清、耳积液炎性介质水平均低于对照组，两组治疗后的检测结果之间均有显著性差异（ P均<0.05）。结论氨溴索治疗分泌性中耳炎的临床疗效较好，对于血清、耳积液炎性介质的改善也较为明显，治疗分泌性中耳炎的应用价值较高。
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