目的：探讨门冬胰岛素对妊娠期糖尿病（GDM）的作用及对子代心脏结构和功能的影响。方法选择GDM 孕妇48例，随机分为两组，研究组24例采用门冬胰岛素治疗；对照组24例采用生物合成的人胰岛素，随访两组疗效及母儿结局，并随访两组子代心脏彩超各项参数结果，以正常孕妇（正常组）24例的子代作为正常组对照。结果研究组血糖达标时间明显短于对照组，胰岛素用量也显著低于对照组（ P 均<0.05）。研究组与对照组的主要母儿结局均无统计学差异（ P 均﹥0.05）。研究组子代在左室收缩期末期容积、二尖瓣 E/ A 峰比值、左室 Tei 指数与对照组有统计学差异（ P 均<0.05），其值更接近于正常组。结论门冬胰岛素起效快、降血糖效果好，其治疗后的妊娠期糖尿病患者的1岁婴儿的心脏结构与功能更接近正常孕妇的子代，值得推广。%Objective To explore the effect of insulin aspart in treatment of patients with gestational diabetes(GDM)and its influence on cardiac function of their offspring. Methods A total of 48 pregnant women in this hospital were collected,24 cases of these pregnant women with GDM treated by insulin aspart were allocated in study group,and 24 pregnant women with GDM using biosynthetic human insulin were composed of control group. The efficacy and outcome were followed - up in these two groups. Echocardiographic parameters of patients in two groups were fol-lowed - up,and 24 cases of normal offspring were collected as normal group. Results The duration for control of blood level of glucose in study group was significantly shorter than that of control group. The amount of insulin was also significantly less than that of control group( P < 0. 05). Main obstetric outcomes between study group and control group were not statistically different( P ﹥ 0. 05). Left ventricular systolic volume,mitral E / A peak ratio,left ventricular Tei index were significantly different between study group and control group( P < 0. 05),and its value was closer to that of normal group. Conclusion Hypoglycemic effect of insulin aspart was more rapid. Cardiac construction in offspring of patients with GDM and their functional indicators were closer to those of offspring of normal pregnant women,and therefore it is worthy to be widely applied.
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