首页> 中文期刊> 《临床和实验医学杂志》 >血游离三碘甲状腺原氨酸与冠状动脉钙化程度的相关性及对主要心血管事件的影响

血游离三碘甲状腺原氨酸与冠状动脉钙化程度的相关性及对主要心血管事件的影响

         

摘要

Objective To analyze blood FT3 and severity of coronary artery calcification and influence of major cardiovascular events. Meth-ods A retrospective analysis of outpatients suspicious clinical data of 120 patients with coronary heart disease. All patients underwent FT3,dual -source CT coronary testing. The patients were divided into two groups according to the level of FT3,the control group(62 cases)with normal FT3, and research group with low FT3(58 patients). According to the coronary artery calcium score(CACS),patients were divided into two groups, CACS≤100 group(75 cases),CACS > 100 group(45 cases);during 8 -30 months follow - up,record the occurrence of adverse cardiovascular e-vents,and perform logistic regression to analyze the relationship of coronary artery calcification,MACE relevant factors. Results MACEin the study group was 15. 52% ,significantly higher than the control group 3. 23%(P 100 packets(5. 56% ),was significantly higher than CACS≤100 packet(2. 67% ),FT3(3. 89 ±0. 58)pmol/ L was significantly lower than that(4. 34 ±0. 61)pmol/ L( P 100分组45例;对所有患者进行8~30个月随访,记录不良心血管事件(MACE)发生情况,并采用 Logistic 回归分析冠状动脉钙化、MACE 相关因素。结果研究组 MACE15.52%显著高于对照组的3.23%( P 100分组 MACE15.56%、显著高于 CACS≤100分组2.67%,FT3(3.89±0.58) pmol/ L 显著低于 CACS≤100分组(4.34±0.61)pmol/ L( P <0.05);Logistic 回归分析显示:FT3水平与冠状动脉钙化、MACE 均相关(OR =0.442、OR =0.366,P <0.05)。结论血 FT3与冠状动脉钙化程度紧密相关相关,低 FT3水平是心血管事件发生危险因素,冠状动脉钙化程度越重,心血管事件发生几率越高。

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