不同BMI指数与高血压患者靶器官功能损伤的关联性分析

摘要

目的 探讨不同体重指数(BMI)与高血压患者靶器官功能损伤的关联性.方法 自2012年1月至2012年12月,前瞻性收集原发性高血压患者100例,根据患者BMI分为研究组(BMI≥25 kg/m2)和对照组(BMI0.05).与对照组比较,研究组3年后颈动脉内膜中膜厚度水平显著增高[(1.45±0.16)mm vs.(1.27±0.15)mm,P=0.000];肾小球滤过率水平显著降低[(101.39±12.84)ml/min vs.(113.84±11.49)ml/min,P=0.000];左室质量指数水平显著降低[(65.73±4.28)g/m2 vs.(70.48±3.95)g/m2,P=0.012];收缩压水平显著增高[(164.48±12.48)mmHg vs.(152.58±11.47)mmHg,P=0.000].研究组入院时和3年后高密度脂蛋白胆固醇水平均低于对照组(P=0.000).两组患者入院时和3年后低密度脂蛋白胆固醇差异均无统计学意义(P>0.05).结论 BMI水平增加是高血压病患者靶器官功能损伤的危险因素.%Objective To investigate the relationship between body mass index (BMI)and target organ injury in patients with hyperten-sion. Methods From Jan,2012 to Dec,2012,100 patients with primary hypertension were prospectively studied. According to the patients'BMI,all patients were assigned into study group (BMI≥25 kg/ m2)or control group (BMI 0. 05). After 3 years,when compared with the control group,patients in the study group got a significantly higher IMT level [(1. 45 ± 0. 16)mm vs. (1. 27 ± 0. 15)mm,P = 0. 000];a significantly lower level of GFR [(101. 39 ± 12. 84)ml/ min vs. (113. 84 ± 11. 49)ml/min,P = 0. 000]. A significantly lower level of left ventricular mass index level [(65. 73 ±4. 28)g/ m2 vs. (70. 48 ±3. 95)g/ m2 ,P =0. 012];and a significantly higher level of systolic blood pressure [(164. 48 ± 12. 48)ml/ min than 152. 58 ± 1. 147 ml/ min,P = 0. 000)]. Patients in the study group had higher levels of high density lipoprotein than the control group on admission and 3 years later (P = 0. 000). There was no sig-nificant difference in low density lipoprotein between the two groups on admission and 3 years later. Conclusion The increase of BMI was a risk factor for targeted organ injury in patients with hypertension.