子宫内膜癌患者临床病理资料特点与淋巴结转移的相关性分析

摘要

目的 回顾性分析子宫内膜癌患者的临床病理资料,探讨临床病理资料特点与淋巴结转移的相关性.方法 纳入2011年1月至2012年12月诊断为子宫内膜癌患者210例,回顾性分析患者临床病理资料,并针对患者的复查等情况进行后续随访,随访病例截止时间为2015年12月,了解患者的淋巴结转移情况.采用Logistic回归分析患者出现淋巴结转移的高危因素.结果 210例宫颈癌患者共22例出现淋巴结转移阳性,转移率10.48%.其中17例(77.27%)为盆腔淋巴结转移;2例(9.09%)为腹主动脉旁淋巴结转移;3例(13.64%)盆腔及腹主动脉旁淋巴结转移.根据患者临床病理资料进行单因素分析结果显示:病灶大小、分化程度、组织学分期、肌层浸润、CA125和脉管转移与淋巴结转移相关(P<0.05),比较具有统计学意义;多因素Logisic回归分析:病灶大小、组织学分期、肌层浸润和CA125为患者出现淋巴结转移的高危因素.结论 子宫内膜癌发生淋巴结转移部位主要为盆腔淋巴结.子宫内膜癌病灶≥2、组织学分期为G3、CA125升高是淋巴结转移的高危因素,临床上应予以重视.%Objective To explore the relationship of clinical and pathological characteristics and lymph node metastasis.Methods From January 2011 to December 2012, clinical and pathological data of 210 cases endometrial cancer patients were retrospectively analyzed.The condition of the patient were followed up.Follow-up deadline was December 2015.Lymph node metastasis data was collected.Logistic regression was performed to analyze risk factors in patients with lymph node metastasis.Results There was a total of 22 cases of lymph node metastasis among 210 cases of cervical cancer, the incidence of metastasis was 10.48%.Of which 17 cases (77.27%) of pelvic lymph node metastasis;2 cases (9.09%) of paraaortic lymph node metastasis, 3 cases (13.64%) and pelvic and para-aortic lymph node metastases.The clinical and pathological data of patients according to univariate analysis showed that: tumor size, degree of differentiation, histological stage, myometrial invasion, CA125 and vascular metastasis were correlated with lymph node metastasis with significant difference (P<0.05);multivariate Logisic Regression analysis showed that: tumor size, histological stage, myometrial invasion and CA125 were the risk factors of patients with lymph node metastasis.Conclusion Endometrial cancer lymph node metastases mainly occurred in pelvic lymph nodes.Endometrial cancer lesions ≥2, histological stage of G3, CA125 are high risk factors of lymph node metastasis, which should be paid more attention.