目的 探究分析多次短时蓝光照射对新生儿黄疸患者血清胆红素浓度及其不良反应的影响.方法 随机选取2013年10月至2015年10月期间收治的100例新生儿黄疸患者为研究对象,将其随机分为对照组(n=50)和观察组(n=50),对照组新生儿黄疸患者应用传统连续蓝光照射(16 h/次,1次/d),观察组患儿应用短时多次蓝光照射(8 h/次,间隔4 h,2次/d)治疗,对比分析两组患者的临床疗效、平均住院时间、黄疸消退时间以及血清总胆红素水平和不良反应发生情况.结果 观察组临床治疗总有效率(90.0%)显著高于对照组(80.0%),观察组患者的平均住院时间(4.11±0.83 d)及黄疸消退时间(40.82±5.03)h明显短于对照组(8.33±0.92 d,58.71±7.33)(P<0.05),且观察组患者的血清总胆红素水平(77.2±15.63)μmol/l明显低于对照组(120.3±22.33)μmol/l,观察组患者无不良反应发生,对照组出现2例(4.0%)腹泻.结论 与传统蓝光照射相比,新生儿黄疸患者应用多次短时蓝光照射的临床效果显著,能够缩短住院时间及黄疸消退时间,明显降低患者血清胆红素水平,且不良反应发生率低,值得临床推广应用.%Objective To explore the effect of multiple short term irradiation with blue light on serum bilirubin concentration in patients with neonatal jaundice and the impact of adverse reactions.Methods A total of 100 patients with neonatal jaundice in this hospital during October 2013 to October 2015 admitted in this hospital were randomly allocated in this study, they were randomly divided into control group (n=50) and observation group (n=50).Patients in control group were treated with traditional continuous blue light irradiation (16 h/time, once per day), patients in observation group were applied with multiple short term blue light irradiation (8 h per time with interval of 4 h, 2 times per day), and their clinical efficacy had been compared between these two group.The average duration of hospital stay, the time for disappearance of jaundice, the level of serum total bilirubin and incidence of adverse reactions were compared between these 2 groups.Results The total effective rate (90.0%) of patients in observation group was significantly higher than that (80.0%) of patients in control group, and the average duration for hospitalization (4.11±0.83 d) and the time for for subsidence of jaundice (40.82±5.03 h) were significantly better than those (8.33±0.92 d,58.71±7.33) of patients in control group (P<0.05), and the level of total serum bilirubin (77.2±15.63) μmol/L in patients of observation was significantly lower than those (120.3±22.33) μmol/L of patients in control group.There was no adverse reaction occurred in patients of observation group, and diarrhea occurred in 2 cases (4%) of control group, and the difference between these two groups had statistical significance (P<0.05).Conclusion The clinical applcation of short-term blue light irradiation for many times in patients with neonatal jaundice can shorten the duration for hospital stay and the time for subsidence of jaundice with low incidence of adverse reactions, hence it is worthy to be clinically popularized and applied.
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