Objective To observe the effects of intravenous pretreatment with dexmedetomidine on postoperative pain and remifentanil-induced hyperalgesia in patients. Methods Eighty patients (ASA I or Ⅱ) scheduled for gynecologic laparoscopic surgery were randomly divided into four groups (n = 20 in each group): low-dose (group L), middle-dose (group M), high-dose (group H) group and control group (group C). Before induction of anesthesia, patients in group L, M and H were given an intravenous infusion of 0. 2 jug/kg, 0. 4 /μg/kg and 0. 8 /μg/kg dexmedetomidine, patients in group C were injected with saline, respectively. Surgery duration, extubation time, sedation score, the scores of VAS and the incidences of adverse effects were recorded. Results The VAS scores of group L, group M and group H were significantly lower than that of group C (P展开▼
