乙琥胺对七氟醚诱发幼鼠躁动的抑制作用

摘要

目的 观察乙琥胺对七氟醚诱发幼年大鼠躁动的抑制作用.方法 SD大鼠,9～11日龄,体重17～23 9.取12只实验动物,随机分为生理盐水组(100μl,腹腔注射)和乙琥胺组(4mg/100μl,腹腔注射),每组6只.持续吸入1％七氟醚,每隔2分钟记录1次躁动评分(PAHBs评分),总观察时间为10 min.另取10只实验动物,同样分为生理盐水组(100μl,腹腔注射)和乙琥胺组(4mg/100μl,腹腔注射),每组5只.持续吸入1％七氟醚,每隔2分钟监测1次额叶脑电功率谱强度值,总监测时间为10 min.结果 1％七氟醚处理时2、4、6、8和10 min乙琥胺组PAHBs评分均明显低于生理盐水组(P＜0.05),额叶脑电功率谱强度值明显低于生理盐水组(P＜0.05).结论 乙琥胺可以降低七氟醚诱发躁动幼年大鼠的额叶脑电功率谱强度值,对七氟醚诱发的幼年大鼠躁动有明显的抑制作用.%Objective To investigate the inhibitory effect of ethosuximide,an antiepileptic drug,on sevoflurane-induced emergence delirium in neonatal rats.Methods Twelve SD rats (17-23 g) at postnatal day 9-11 were randomly divided into ethosuximide group (4 mg/100 μl,intraperitoneal injection,n=6) and saline group (100 μ1,intraperitoneal injection,n =6).Then the pups were treated with 1％ sevoflurane for 10 minutes and agitated behaviors was observed using PAHBs scoring method for every 2 minutes.Ten more pups were randomly divided into two groups as previously described.Then the pups were treated with 1％ sevoflurane for 10 minutes and EEG power spectrum of frontal lobe was monitored for every 2 minutes.Results Both PAHBs scores and EEG power spectrum at 2 min,4 min,6 min,8 min and 10 min were significantly decreased in ethosuximide group when comparing with saline group under 1％ sevoflurane inhalation (P ＜ 0.05).Conclusion Ethosuximide can decrease frontal lobe EEG power spectrum in sevoflurane-induced agitated rats and inhibit sevoflurane-induced emergence delirium in neonatal rats.