颈动脉峰值流速变异率评估腹腔镜手术患者容量反应性的价值

摘要

Objective To assess the accuracy and feasibility of respirophasic variation in carotid artery blood flow peak velocity (△Vpeak-CA) as predictors of fluid responsiveness in laparoscopic surgery.Methods Fifty-five patients undergoing laparoscopic surgeries,29 males and 26 females,aged 45-75 years,ASA physical status Ⅰ-Ⅲ,with body mass index 20-24 kg/m2,were enrolled.When intra-abdominal pressure was steady at the level of 13-15 mm Hg,6％ hydroxyethylstarch (HES 130/0.4) 500 ml was infused at the speed of 7 ml/kg within 20 minutes.After volume expansion,subjects were classified as responders (group R,n =32) if cardiac index increased (△CI) was≥ 15％ and no responders (group NR,n =23) as △CI＜15％.The receiver operating characteristic curve (ROC) curve for △Vpeak-CA in determining the volume expansion responsiveness was plotted,and the diagnostic threshold was determined.The area under curve (AUC) and 95 ％ confidence interval (CI) was calculated.Cardiac index (CI),△Vpeak-CA and stroke volume variation (SW) were independently recorded at 5 minutes after induction (T1),5 minutes after intra-abdominal pressure were stable at the level of 13-15 mm Hg (T2) and 5 minutes after volume expansion (T3).Results △Vpeak-CA is highly negatively correlated with CI (r=-0.843,P＜0.001).The results of ROC curve analysis showed,△Vpeak-CA threshold discriminated between responders and non-responders with a sensitivity of 81.3％ and a specificity of 91.3％,and the AUC was 0.884 (95％ CI 0.793-0.975).Conclusion △Vpeak-CA seems to be a highly feasible and reliable predictor for fluid responsiveness in laparoscopic surgery patients.%目的 探讨颈动脉峰值流速变异率(respirophasic variation in carotid artery blood flow peak velocity,△Vpeak-CA)评估腹腔镜手术患者容量反应性的准确性和可行性.方法 选择择期行腹腔镜下手术患者55例,男29例,女26例,年龄45～75岁,BMI 20～24 kg/m2,ASA Ⅰ～Ⅲ级.在气腹压稳定于13～15 mm Hg后,20 min内快速静脉输注羟乙基淀粉130/0.4氯化钠注射液7ml/kg.以心脏指数(cardiac index,CI)的增长量(△CI)≥15％作为液体反应阳性的判定标准,分为有反应组(R组,n=32)和无反应组(NR组,n=23),并绘制△Vpeak-CA判断容量变化的受试者工作特性曲线(receiver operating characteristic curve,ROC),计算诊断阈值、曲线下面积(area undercurve,AUC)和95％o可信区间(CD.记录麻醉诱导后5 min(气腹前,T1)、气腹压上调稳定于13～15 mmHg5min后(T2)、补液后5 min(T3)的每博变异率(SVV)、△Vpeak-CA和CI.结果 气腹下补液前△Vpeak-CA与CI呈高度负相关(r=-0.843,P＜0.001).△Vpeak-CA评估容量反应性的ROC曲线的AUC为0.884 (95％CI 0.793～0.975),诊断阈值为17.85％,判断液体反应性的灵敏度为81.3％,特异度为91.3％.结论 △Vpeak-CA可作为腹腔镜手术患者评估容量反应性的可靠指标.