外周血内皮祖细胞在高血压性脑出血不同时期患者中的动态变化分析

摘要

Objective To investigate the dynamic changes of endothelial progenitor cells (EPCs) in peripheral blood of patients with hypertensive cerebral hemorrhage.Methods Flow cytometry was used to detect the dynamic changes of EPCs in 79 cases of hypertensive cerebral hemorrhages as the experimental group and 70 cases of normal healthy people as the control group.Results In the acute phase after hemorrhage (3 days),EPCs in experimental group [(51.3 ±9.3) × 103/ml,(52.0 ±6.3) × 103/ml,(53.1 ±9.3) × 103/ml] were significantly lower than the control group [(75.4 ± 15.6) × 103/ml] (P ＜0.05).However,after that the level of EPCs in experimental group [(110.9 ± 12.0) × 103/ml,(132.8 ± 11.8)× 103/ml,(115.3 ±9.9) × 103/ml] increased rapidly and was significantly higher than the control group (P ＜0.05),and approximately two weeks later it reduced to normal levels [(83.1 ±7.9) × 103/ml].Conclusions In patients with hypertensive cerebral hemorrhage,the levels of EPCs in peripheral blood were closely related with the disease and might become a prognostic marker.%目的 分析外周血内皮祖细胞(EPCs)在高血压性脑出血不同时期患者中的动态变化情况.方法 选择2012年6月至2014年6月收治的79例高血压性脑出血患者为研究组,另选资料匹配的健康体检者70例为对照组,观察记录患者入院时及入院后第1、3、5、7、14、21天(T0～6)时外周血中EPCs动态变化情况.结果 研究组T0～2时外周血EPCs[(51.3±9.3)×103/ml、(52.0±6.3)×103/ml、(53.1 ±9.3)×103/ml]均明显低于对照组[(75.4±15.6)×103/ml](P＜0.05),之后研究组T3 ～5时EPCs[(110.9士12.0)×103/ml、(132.8±11.8)×103/ml、(115.3±9.9)×103/ml]升高,均明显高于对照组(P＜0.05),在T6时降为正常水平[(83.1±7.9)×103/ml].外周血EPCs随着格拉斯哥评分(GCS)降低而降低,与对照组分别比较差异也均有统计学意义(P＜0.05).线性回归分析显示研究组患者外周血EPCs与血小板(PLT)水平呈显著的线性相关(r=0.681,P＜0.05).结论 高血压性脑出血患者不同时期外周血EPCs水平与病程进展有密切关系,可能会作为另一种判断高血压性脑出血预后标志物.