血清IFN-、IL-18及IL-10与复发性流产的相关性研究

摘要

目的探讨血清中IFN-γ、IL-18及IL-10的水平与复发性流产(RSA)的关系.方法 采用酶联免疫吸附法检测复发性流产患者40例(RSA组)及正常早孕妇女40例(对照组)血清IFN-γ、IL-18及IL-10的水平,2个月后随访,再次测定两组对象未孕状态时血清各细胞因子的水平.结果 RSA组流产发生时血清IFN-γ、IL-18水平显著高于对照组(P＜0.01);而IL-10水平显著低于对照组(P＜0.01);两组患者终止妊娠2个月后,在未孕状态时血清IFN-γ、IL-10的水平差异无统计学意义(P＞0.05),而RSA组血清IL-18水平持续维持高水平状态.结论 复发性流产患者血清IFN-γ、IL-18水平升高而IL-10水平降低,IFN-γ、IL-18及IL-10与复发性流产的关系密切.%Objective To explore the correlation between the serum levels of interferon (IFN)-γ,interleukin (IL)-18,IL-10 and recurrent spontaneous abortion (RSA).Methods Enzyme-linked immunosorbent assay was used to detect the serum levels of IFN-γ,IL-18 and IL-10.There were 40 patients with RSA (RSA group) and 40 normal early pregnant women (control group) enrolled in this study.After 2 months,those serum cytokines in two groups of non-pregnant state were detected again.Results Compared to control group,the serum levels of IFN-γ and IL-18 of RSA group were significantly higher (P ＜0.01),the serum level of IL-10 was significantly lower (P ＜ 0.01).Two months after termination of pregnancy,there was no significant difference in the serum levels of IFN-γ and IL-10 between the two groups.The serum level of IL-18 maintained a high level in the RSA group after termination of pregnancy.Conclusions In patients with RSA,the serum levels of IFN-γ and IL-18 were elevated,the serum level of IL-10 was decreased.The serum levels of IFN-γ,IL-18 and IL-10 were closely related with RSA.