海洋天然产物片螺素及其相关吡咯生物碱近期研究进展

摘要

片螺素(lamellarin)及其相关的吡咯生物碱是一类从海洋生物中分离得到的具有新颖结构和显著生物活性的海洋生物碱.其结构特征是都具有3,4-二芳基-2-酸酯或酰胺母核.本综述概述了近期关于lamellarin及其相关吡咯生物碱的提取分离、全合成、生物活性及其构效关系等方面的研究.%Lamellarins and related pyrrole-derived alkaloids are a large family of marine alkaloids with novel structures and promising bioactivities.They have been isolated from diverse marine organisms and all of them feature a 3,4-diarylpyrrole 2-carboxylic acid ester or amide moiety.This article provides an overview of recent literatures on lamellarins and related pyrrole-derived alkaloids,including their isolation,total synthesis,biological and structure activity relationshil (SAR) studies.