Cold-spray Ionization Mass Spectrometry for Characterization of Biomolecules in Solution

摘要

@@ A direct solution analysis method, coldspray ionization (CSI) mass spectrometry (MS)[1], a variant of electrospray (ESI) MS operating at low temperature (ca. - 80 ～ 10℃), allows facile and precise characterization of labile organic species, especially those in which non-covalent bonding interactions are prominent. We have applies this method to investigations of the solution structures of many labile organic species, including unstable reagents and reaction intermediates, asymmetric catalysts, supramolecules, and even primary biomolecules.