纤支镜联合氨溴索与阿米卡星灌洗治疗重型颅脑损伤合并重症肺炎的临床观察

摘要

Objective To analyze the clinical effect of Ambroxol and amikacin sequential lavage under Bronchofiberscope for the treatment of severe craniocerebral injury with severe pneumonia.Methods 82 cases of patients severe craniocerebral injury with severe pneumonia were selected and randomly divided into experimental group(41 cases) and control group(41 cases).The control group were given routine therapy treatment, on the basis of the control group, experimental group were treated with Ambroxol and amikacin sequential lavage under Bronchofiberscope. Compared treatment effect, sputum bacteriology changes before and after the treatment and take off the breathing machine time between two groupsResults The total effective rate in the experimental group(97.56%) was significantly higher than control group(78.05%), with statistical significance(P 0.05).At the same time, the takeing off the breathing machine time in experimental group was significantly higher than that of control group(P< 0.05).Conclusion On the basis of conventional treatment, Ambroxol and amikacin sequential lavage under Bronchofiberscope can improve the treatment effect, shorten the time of bacteria turnning negative, and decrease the time of the breathing machine, so it has good clinical application value.%目的：研究纤支镜联合氨溴索与阿米卡星灌洗治疗重型颅脑损伤合并重症肺炎的临床效果。方法选取82例重型颅脑损伤合并重症肺炎患者，将其随机分成试验组（n＝41）和对照组（n＝41），对照组给予常规疗法进行治疗，试验组在对照组的基础上给予纤支镜联合氨溴索与阿米卡星灌洗治疗，对比分析两组治疗效果、治疗前后痰细菌学变化及脱呼吸机时间。结果经过治疗，试验组的治疗总有效率为97.56%，显著高于对照组的78.05%，差异具有统计学意义（P＜0.05）。治疗14 d后，两组的各类细菌阳性检出率显著下降，且试验组明显低于对照组（P＜0.05），而到治疗后42 d时两组细菌阳性检出率无明显差异（P＞0.05）。同时试验组患者脱呼吸机时间显著短于对照组（P＜0.05）。结论在常规治疗的基础上，给予纤支镜联合氨溴索与阿米卡星灌洗疗法可提高重型颅脑损伤合并重症肺炎的治疗效果，缩短细菌阴转时间，并缩短呼吸机的使用时间，具有良好的临床应用价值。