Objective To study the antipyretic and anti-inflammatory effects of total flavonoids in Abelmoschus manihot. Methods Intravenous injection of E. Coli liquid into rabbits resulted in fever model of rabbits and its antipyretic effect was observed. Xylene was used to induce ear swelling and resulted in acute inflammation model,and the anti-inflammatory effect was observed. Results Oral intake of total flavonoids in abelmoschus manihot on the dosage of 60 mg/kg or 120 mg/kg significantly inhibited E. Coli-induced fever of rabbits,and lowered the peak temperature; Topical application of total flavonoids could reduce the swelling rate of external ear in mice. Conclusion The total flavonoids in abelmoschus manihot have some antipyretic and anti-inflammatory effects.%目的 研究金花葵花总黄酮的解热和抗炎作用.方法 采用大肠杆菌液静脉注射家兔的方法,制成家兔发热模型,观察其解热作用；采用二甲苯致小鼠耳片肿胀的方法,造成急性炎症模型,观察其抗炎作用.结果 金花葵花总黄酮60 mg/kg、120mg/kg灌胃能明显抑制大肠杆菌所致的家兔体温升高,使体温峰值降低；局部涂抹能降低二甲苯致炎小鼠耳廓肿胀率.结论金花葵花总黄酮具有一定的解热和抗炎作用.
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