不同病理阶段肺腺癌性磨玻璃结节PET/CT表现差异分析

摘要

Objective:To investigate and control analyse the 18F-FDG PET/CT features of lung adenocarcinoma presenting as isolated ground-glass nodules (GGN).Methods:Sixty-eight lung adenocarcinoma presenting as isolated GGN confirmed by surgery pathology were included in this study.The lesions were divided into three groups:precancerous lesions(atypical adenomatous hyperplasia(AAH) and adenocarcinoma in situ(AIS)),microinvasive adenocarcinoma(MIA),invasive adenocarcinoma(IAC).The lesion size,solid portions,morphological feature,metabolism characteristic on the preoperative 18F-FDG PET/CT images in the three groups were analyzed and compared with pathological results.The data were statistically analyzed using SPSS 17.0.Results:The lesion size,solid portions,morphological feature,SUVmax gradually increased from precancerous lesions to IAC.There were statistically significant differences in lesion size and solid portions between the precancerous lesions and MIA groups (P＜0.05).There were statistically significant differences in the lesion size,solid portions,morphological feature and metabolism characteristic between MIA and IAC groups(P＜0.05,all).Conclusion:Comprehensive analysis of the 18F-FDG PET/ CT image features of GGN,may be helpful for the diagnosis and distinguish diagnosis of precancerous lesions,MIA and IAC.%目的:探讨不同病理阶段肺腺癌性磨玻璃结节(GGN)的18F-FDG PET/CT影像学特征.方法:依据病理将68例病灶分为浸润前病变(不典型腺瘤样增生(AAH)和原位腺癌(AIS))、微浸润腺癌(MIA)和浸润性腺癌(IAC)3组,回顾性分析各组GGN的实性成分比例、形态学、大小和SUVmax值,并对数据的差异分别进行统计分析.结果:从浸润前病变、MIA至IAC,GGN实性成分比例、分叶毛刺征比率、大小、SUVmax逐渐增高.浸润前病变组与MIA组是否纯磨玻璃结节及大小的差异有统计学意义(P＜0.05).MIA组与IAC组的实性成分比例、分叶毛刺征比率、大小及SUVmax的差异均有统计学意义(均P＜0.05).结论:综合分析GGN的18F-FDG PET/CT影像学特征,可对不同病理阶段腺癌性GGN的诊断和鉴别诊断提供帮助.