TO ACTIN RESISTANT VARIANT OF HUMAN DN-ase I EXHIBITING HYDROLYTIC ACTIVITY OF DNA SPLITTING AND ISOLATED NUCLEIC ACID ENCODING THEREOF AS WELL AS METHOD OF TREATING A PATIENT SUFFERING FROM LUNG DISEASE OR A DISEASE COMPRISING THERAPEUTICAL ADMINISTRATION OF A CERTAIN AMOUNT OF THE HUMAN DN-ase I RESISTANT TO ACTIN, AND PHARMACEUTICAL PREPARATION CONTAINING SUCH ACTIN-RESISTANT VARIANT OF THE HUMAN DN-ase EXHIBITING DNA SPLITTING HYDROLYTIC ACTIVITY

摘要

The present invention relates to amino acid sequence variants of human DNase I that have reduced binding affinity for actin. The invention provides nucleic acid sequences encoding such actin-resistant variants, thereby enabling the production of these variants in quantities sufficient for clinical use. The invention also relates to pharmaceutical compositions and therapeutic uses of actin-resistant variants of human DNase I.