PET/CT TRACER HAVING SELECTIVITY FOR DIFFERENT LUNG CANCER CELLS, PREPARATION METHOD THEREFOR AND USE THEREOF

摘要

A PET/CT tracer having selectivity for different lung cancer cells, a preparation method therefor and use thereof. The PET/CT tracer is a compound represented by formula I, or a salt or stereoisomer thereof, wherein R₁ and R₂ are each independently selected from H or C₁-C₅ alkyl, and X is independently selected from ¹¹C, ¹⁸F, ¹⁹F, ¹⁵O, or ¹³N. The prepared ¹⁸F-PET/CT tracer can be selectively taken in by different carcinogenic driver gene mutant lung cancer cells. Test results show that the ¹⁸F-PET/CT tracer is expected to achieve high quality imaging in an NRas Q61K tumor model, and has certain selectivity for different carcinogenic driver gene mutant lung cancers. The tracer is different from ¹⁸F-FDG that may lead to high-concentration imaging in any lesion due to increased glucose metabolism, and is expected to make up for the deficiency of imaging by using ¹⁸F-FDG alone. Therefore, the ¹⁸F-PET/CT tracer is expected to be applied to PET/CT iconography and change the situation of lack of tracers on lung cancers.