测定40例绝经前后正常妇女及30例绝经后冠心病（CHD）妇女性激素、血浆降钙素基因相关肽（CGRP）和内皮素（ET-1）水平。将30例冠心病（CHD）妇女随机分为两组，治疗组服尼尔雌醇，对照组服用安慰剂，疗程24周。结果显示，绝经后妇女雌激素（E2）、降钙素基因相关肽（CGRP）降低，睾酮（T）、内皮素（ET-1）升高，而女性冠心病患者此种改变更显著；E2与CGRP呈正相关，与ET-1呈负相关；T与ET-1、CGRP相关程度不显著；尼尔雌醇治疗后CGRP上升，ET-1下降。提示雌激素对血管内皮细胞有一定效应，这可能是其心血管保护作用的重要机制之一。%Objective To investigate the relationship between sex hormone levels and blood calcitonin gene-related peptide/endothlin-1, and to evaluate the therapeutic effects of nylestriol. Methods Forty perimenopausal women without coronary heart disease (CHD) and 30 postmenopausal women with CHD were studied, and 30 postmenopausal women were divided into two groups and treated randomly with either 2mg nylestriol or pacebo. Serum 17β-estradiol (E2), testosterone (T), plasma calcitonin gene-related peptide (CGRP) and endothelin-1 (ET-1) were measured. Results In postmenopausal women, serum levels of E2 and plasma concentrations of CGRP decreased, while serum levels of T and plasma concentrations of ET-1 increased; E2 was positively related to CGRP, and negatively related to ET-1; T was negatively related to CGRP or ET-1. In the nylestriol group, compared with the paramters before treatment, plasma CGRP increased and ET-1 decreased after treatment. Conclusion Estradiol possesses certain effects on endothelial cell, which may be an important aspect of its protective effects.
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