PEPTIDE ANTAGONISTS OF PEPTIDE HORMONES FROM THE CALCITONIN GROUP (CALCITONIN GENE-RELATED PEPTIDES (CGRP)) AND THEIR APPLICATION

摘要

FIELD: biotechnology.;SUBSTANCE: invention relates to peptide antagonists of calcitonin gene-related peptide (CGRP), and can be used in medicine for treatment of a condition associated with elevated levels of CGRP, including migraine. A peptide with a structure X¹- Y¹- Z¹ structure is proposed, where X¹ has the X¹¹-X¹²-X¹³-X¹⁴-X¹⁵-X¹⁶-X¹⁷ structure (SEQ ID #16), where X¹⁷ is Cys, where X¹¹ is selected from the group consisting of Ala, Cys and Gly, and where X¹² is selected from the group consisting of Cys and Ser, provided that one of X¹¹ or X¹² is Cys, where X¹³ is selected from the group consisting of Arg, Asn, Asp and Val, where X¹⁴ is selected from the group consisting of Leu, Phe and Thr, where X¹⁵ is selected from the group consisting of Ala, Gly and Ser, where X¹⁶ is selected from the group consisting of Ala, Ile, Leu, Ser, and Val. At that, Y¹ is Val-Leu-Gly-Arg-Leu-Ser-Gln-Glu-Leu-His-Arg-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn- (SEQ ID #34); and Z¹ is Val-Gly-Ser-Lys-Ala-Phe-NH₂ (SEQ ID #46).;EFFECT: obtaining of an effective antagonist for CGRP.;23 cl, 7 tbl, 1 ex