藏族人群ABO血型分布及其遗传关系

摘要

目的:了解中国和印度28个藏族群体ABO血型分布特征.方法:采用Phylip3.68 和MEGA4.1遗传分析软件包对基因频率数据进行处理, 输出Nei's遗传距离, 分析他们的遗传关系.结果:甘肃、青海、四川、云南、西藏和印度藏族群体ABO血型表型分布特征为O＞A＞B＞AB, 民族指数和遗传距离分别为0.63～0.98和0～0.0072.结论:各地藏族的先民可能存在一定的历史渊源, 由于其历史上的分化事件不同, 而致不同地区藏族群体ABO血型的基因频率分布特征存在多样性.%Objective To explore the distribution of ABO blood group in Tibetans population and their genetic relationship. Methods Data of ABO blood group of 28 Titetan populations were collected from China and India. The gene frequencies were processed by Phylip3. 68 and MEGA4. 1 genetic analysis software pack, and the Nei's genetic distance was imported and the genetic relationship was analyzed. Results The distribution of ABO blood group among Gansu, Qianghai, Sichuan, Yunnan, Tibet, and India was 0 ＞ A ＞ B ＞ AB. The nation index and genetic distance were 0. 63 ～ 0.98 and 0 ～0. 0072, respectively. Conclusion There is probable historical relationship among the ancestors of these Tibetan populations, but the differentiation incident of Tibetan population living in different area in history was different, so that their distribution of gene frequencies is diversified.