IgA肾病分子遗传学研究新进展

摘要

Immunoglobulin A nephropathy (IgAN) , which can develop into end-stage renal disease, is the most common primary glomerulonephritis. The pathogenesis of IgAN is not clear. Many studies have confirmed that genetic susceptibility is associated with IgAN, and it belongs to polygenic disease. Some studies have found that IgAN is associated with chromosome 6q22-23 , 2q36 by linkage analysis, and several candidate genes have been confirmed to be associated with IgAN, such as angiotensin converting enzyme, Fc fragment of IgA receptor, human leukocyte antigen. In recent years, as the progression of molecular genetics and the Human Genome Project, more attention has been paid to the role of genetic factors in the pathogenesis of IgAN.%IgA肾病(immunoglobulin A nephropathy,IgAN)是最常见的原发性肾小球肾炎,也是引起终末期肾脏疾病的一个重要原因.其具体的发病机制尚不明确,许多研究证实其与遗传易感性有关,属于多基因病.连锁分析发现IgAN与染色体6q22-23和2q36等连锁,关联研究发现多个候选基因(如血管紧张素转换酶基因、Fcα受体基因、人类白细胞抗原基因等)与IgAN相关.近年来,随着分子遗传学和人类基因组计划的进展,遗传因素在IgAN中的致病作用越来越受到人们的关注.