Objective To assess definition whid was optimal for chinese on Metabolic Syndrome ( MS ). Methods 1903 individuals for health physical examination were enrolled and MS patients were identified with three definitions of MS respectively. To analyze the association between MS and Cerebral Atherosclerosis. Result The prevalence of MS was 14. 14% ,27. 33% and 29. 69% according to CDS, IDF and ATPIH definition and the corresponding Cerebral Atherosclerosis in MS was 20. 07%, 15. 77% and 17. 17 % respectively ( x = 2. 307, P = 0. 315 ). Logistic analysis showed that MS wasn't an independent risk factor of Cerebral Atherosclerosis and the effect of MS on predicting ischemic events depended on hyperglycemia and hypertension. The hyperglycemia in CDS definition significantly increased the risk of Cerebral Atherosclerosis with correlation coefficients value 0. 734( IDF, ATPIII all = 0.651, Z value =2.02, P<0.05 ). Similar result was obtained about hypertension in CDS definition and cerebral atherosclerosis ( Z = 1. 97 ,P <0. 05 ). Conclusion The effect of MS cerebral atherosclerosis depends on MS components and the cutoff value of hyperglycemia and hypertension in CDS is more suitable of Chinese for screening the high risk group of ischemic events.%目的 探寻更适用于国人的代谢综合征(MS)诊断标准.方法 以1903例健康体检个体为研究对象,比较经不同标准诊断的MS与脑动脉粥样硬化性病变的相关性.结果 ①1903例个体中,经CDS、IDF及改良NCEP ATPⅢ标准诊断的MS患者率分别为14.14%、27.33%及29.69%(χ2=147.78,P<0.0001),相应脑动脉粥样硬化性病变的发生率分别为20.07%、15.77%和17.17%(χ2=2.307,P=0.315).②多因素Logistic回归分析,MS患者增加脑动脉闭塞病变发病风险的作用依赖于其危险组分高血糖、高血压.将三种MS诊断标准中使用的高血糖、高血压与脑动脉闭塞病变的关联相关系数进行比较显示,CDS标准中高血糖、高血压与脑动脉粥样硬化性病变发病风险增加的相关性最强(Z=2.02,P<0.05; Z=1.97,P<0.05).结论 MS对脑动脉粥样硬化性病变的影响取决于其危险组分高血糖、高血压,而CDS诊断标准中高血糖、高血压的界定水平可能更有利于国人脑动脉闭塞病变等高危人群的筛查.
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