两性苯基膦酸铝球不仅具有特殊的核-壳结构,而且还具有两种相反的性质,即阴离子核和阳离子壳,因此能够同时担载阴阳离子.为了考察核-壳结构的两性苯基膦酸铝球作为药物载体的性能,开展了苯基膦酸铝材料对抗癌类药物DOXHCl以及靶向剂叶酸的担载研究,使用分光光度法对DOXHCl及叶酸的担载量进行定量分析.实验结果表明苯基膦酸铝材料能够高效地担载抗癌性药物DOXHCl,同时对靶向剂叶酸的担载量也足以满足对癌细胞的靶向定位需要.%The yolk-shell structure aluminum phenylphosphonate microspheres possess not only a special"core@void@shell"structure,but also two opposite properties in one particle,i. e. anionic core and cationic shell,which makes them adsorb anionic and cationic ions simultaneously. The yolk-shell structure aluminum phenylphosphonate microspheres were used as carriers,their load behavior for doxorubicin hydrochloride of anti-cancer drug and folic acid of targeting agent was investigated by using Ultraviolet-Visible spectrophotometry. The results indicate that aluminum phenylphosphonate microspheres can efficiently load anticancer drug of doxo-rubicin hydrochloride,and load enough folic acid to meet the requirement of targeting to cancer cells.
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