心血管系统中内皮细胞向间充质细胞转分化的研究进展

摘要

Transdifferentiation is a process in which a cell type committed to a particular specialization shifts to another distinct type under some conditions. During the embryonic development or some pathological conditions, the endothelial cells in the cardiovascular system will be transferred to mesenchymal cells with different biological significance. We review the mechanism and the detection method of Endothelial cells to mesenchymal cells transition.%细胞的转分化是一种细胞在某些理化因素作用下转化为另一种细胞的现象.在胚胎发育期或某些病理及压力条件下,心血管系统中内皮细胞会转分化成间充质细胞,并带来不同的生物学意义.本文就心血管系统中内皮细胞向间充质细胞转分化的机制及检测方法进行了综述.