苯并异噻唑啉酮类化合物的生物活性研究

摘要

对合成的5种苯并异噻唑啉酮类化合物进行了生物活性研究.抑菌试验结果表明,化合物a与化合物b对大肠杆菌最小抑菌浓度为12.5mg/L.对金黄色葡萄球菌都表现出良好的抑菌活性.对亚心形扁藻,蛋白核小球藻,球等鞭金藻,化合物都有抑制其生长的活性,亚心形扁藻耐受性最高,球等鞭金藻的耐受性最低,蛋白核小球藻的耐受性居中.%The biological activity of five N-substituted phenyl-2-(benzo-isothiazolin-3-one-2-yl) carbonyl amines was studied. The result showed that compounds a and compounds b of 12. 5mg/L had activity against Escherichia coli. The five compounds showed good antibacterial activity to Staphylococcus aureus. All compounds inhibited the growth activity to the microorganisms like heart-shaped flat on the sub-algae , Chlorella pyrenoidosa , Isochrysis galbana. Among those , the highest activity was the Platymonas subcordiformis , the lowest was Isochrysis galbana.