目的：探讨联合检测血清中的CEA、AFP、CA724、CA199多项肿瘤标志物在消化道肿瘤诊断中的价值。方法采用电化学发光技术对200例消化道恶性肿瘤患者及200例相应良性疾病患者进行CEA、AFP、CA724、CA199测定。结果恶性肿瘤组的四种标志物的表达均高于良性疾病组，差异具有统计学意义；四种标志物联合检测阳性率大于单个指标检测阳性率，差异有统计学意义。结论 CEA 、AFP 、CA724、CA199对于消化道肿瘤的诊断具有重要的临床意义，联合检测可提高诊断消化道恶性肿瘤的阳性率。%Objective To investigate diagnostic value of combined detection of multiple tumor markers CEA ,AFP ,CA724 , and CA199 in digestive tract malignancies .Methods Serum CEA ,AFP ,CA724 ,and CA199 of 200patients with digestive tract malignancies and 200 patients with benign digestive tract diseases were measured by electrochemiluminescence technology .Re sults Four markers of the group with malignancy were higher than the group with benign tumor ,and the differences among them were significant .Positive rate of combined detection of four markers was greater than any individual one ,while significant differences were statistically .Conclusions CEA ,AFP ,CA724 ,and CA199 play important role in clinical detection and diagnosis of digestive tract tumors ,and positive rate of digestive tract cancer can be improved by the combined detection of these four markers .
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