一氧化氮治疗急性坏死性胰腺炎的实验研究

摘要

Objective:To study the mechanism of nitric oxide(NO)donors-arginine in treatment of acute hemorrhagic necrotizing pancreatitis(AHNP).Methods:One hundred and twenty SD rats were divided into 3 groups.Group A was treated with NS,Group B with L-arginine and group C with L-arginine inhibitors.Results:The rats in group B exhibited a low degree of PLA2 and TNF,a high degree of NO(P＜0.01) and the mortality was much lower than that in group A and C.The rats in group B had a longer survival time and less histologic damage than the rats in group A and C.Conclusions:All the results suggest that NO has preventive effect on AHNP.%目的：探讨一氧化氮(NO)的前体物质精氨酸治疗急性坏死性胰腺炎的机制。方法：120只大鼠随机分为胰腺炎对照组(A组)、精氨酸治疗组(B组)和精氨酸抑制剂治疗组(C组)；观察其血清磷脂酶A2(PLA2)、肿瘤坏死因子(TNF)、NO含量，并计算各组腹水量、24h病死率和平均生存时间。结果：B组PLA2和TNF较A、C两组低(P＜0.01)，NO含量较A、C两组高(P＜0.01)，24h病死率较低，平均生存时间长，病理损害较轻。结论：NO对急性坏死性胰腺炎有一定的保护作用。