Acute necrotising pancreatitis as colic reason in a pony.Original Title Akute nekrotisierende Pankreatitis als Kolikursache bei esnem Kleinpferd.

摘要

This case report describes clinical signs, treatment and pathological findings of a 15-year-old pony mare with acute necrotising pancreatitis which was presented due to continuous severe abdominal pain, anorexia, tachycardia (88/min), tachypnoea (68/min), increased body temperature (40,8 degrees C), abdominal distension, absence of abdominal sounds, anuria and no defecation. Increased peritoneal fluid and distended intestinal loops were seen sonographically. Biochemical analysis of venous blood resulted in hyperlipasaemia (>6000 U/l), hypertriglyceridaemia (29,75 mmol/l), hyperglycaemia (40,79 mmol/l) and elevated activities of GLDH- (993,3 U/l), AST- (2663,1 U/l), LDH- (2830 U/l) and GGT (458,8 U/l). Serum insulin was normal (12,1 micro U/ml). Peritoneal fluid was haemorrhagic and had increased activity of lipase (>36000 U/l). The patient was treated with crystalloid (4 ml NaCl 7,5%/kg BW and 100 ml NaCl 0,9%/kg BW) as well as colloidal infusions (10 ml hydroxyl ethyl starch 10%/kg BW) and with Flunixin meglumine (1,1 mg/kg BW i.v.) as analgesic. Due to bad prognosis of general condition the pony was euthanized. Acute necrotising pancreatitis was diagnosed based on the pathologic-anatomical and -histological findings. The pancreas showed extended necrosis with extensive destruction of organ-specific structures and multifocal necrosis in the pancreatic region and mesentery fat. Acute pancreatitis often is an incidental finding during routine necropsy. Clinicians should consider pancreatitis as a differential diagnosis in horses presented with abdominal pain, fever and increased enzyme activity. Especially in horses with hypertriglyceridaemia and hyperglycaemia it is advisable to analyse concentrations of lipase as well as amylase in blood and peritoneal fluid.