血清CA15-3、CA125、CEA和PRL水平与乳腺癌及骨转移的关系

摘要

Objective:To explore the relationship between serum levels of CA15-3,CA125,CEA,PRL and breast cancer with bone metastasis. Methods:The levels of the serum CA15-3,CA125,CEA and PRL in 60 healthy people,67 patients with breast benign hyperplasia and 95 patients with breast cancer were measured with ECLIA,whose were compared in breast cancer patients before and after surgery and before and after bone metastasis. Results:The levels of serum CA15-3,CA125,CEA and PRL in patients with breast cancer were significantly higher than those in patients with breast benign hyperplasia and healthy people(P <0. 01). The levels of serum CA15-3,CA125,CEA and PRL in patients with breast cancer significantly decreased after operation(P<0. 01). The levels of serum CA15-3,CA125,CEA and PRL in patients with bond metastasis were significantly higher than those in patients without bond metastasis. Conclusions:Detecting the levels of serum CA15-3,CA125,CEA and PRL may have important value in diagnosing and judging prognosis of breast cancer(P<0. 01).%目的：探讨血清糖类抗原15-3(CA15-3)、CA125、癌胚抗原(CEA)和催乳素(PRL)水平与乳腺癌及其骨转移的关系。方法：应用化学发光法对60名正常人、67例乳腺良性增生和95例乳腺癌患者CA15-3、CA125、CEA和 PRL水平进行检测，并对乳腺癌患者手术前后和有无骨转移前后各观察指标的水平进行比较。结果：乳腺癌患者血清CA15-3、CA125、CEA和PRL水平均明显高于正常人组和乳腺良性增生组(P<0.01)。乳腺癌组术后血清CA15-3、CA125、CEA和PRL水平均较术前显著降低(P<0.01)。发生骨转移者血清CA15-3、CA125、CEA和 PRL水平均明显高于无骨转移者(P<0.01)。结论：检测乳腺癌患者CA15-3、CA125、CEA和 PRL水平变化，对乳腺癌患者诊断及判断预后具有重要价值。