抗氧化系统对不同年龄患者冠状动脉病变程度的影响

摘要

Objective: To investigate the effects of catalase ( CAT), superoxide dismutase ( SOD) and glutathione system on the coronary heart disease of different age patients. Methods:One hundred and seventy-nine 49 to 90 years old patients with coronary heart disease were divided into the non-senile group(77 cases,less than 60 years old) and senile group(102 cases,more than or equal to 60 years old). The levels of fasting lipid,fasting glucose,CAT,SOD,GSH,GSH-Px and GR,height and weight in all cases were measured. The results of coronary arteriography of all cases were assessed using Gensini score system. Results:The serum levels of GSH,GSH-Px, GR,CAT and SOD in senile group were lower than those in non-senile group(P < 0. 05 to P < 0. 01). There was significantly negative correlation between the levels of GSH,GSH-Px,GR,CAT and SOD,and Gensini scores after righting age(P < 0. 01). The results of multiple linear regression analysis showed that the effects of GSH-Px and CAT on Gensini scores were great. Conclusions:The levels of GSH,GSH-PX,GR,CAT and SOD significantly decrease with the growth of age,which is negative correlation with coronary artery disease. The effects of GSH-Px and CAT on coronary artery disease are great.%目的：：探讨不同年龄患者过氧化氢酶(CAT)、超氧化物歧化酶(SOD)以及谷胱甘肽系统对冠状动脉(冠脉)病变程度的影响。方法：选取179例年龄49~90岁的心内科住院患者,分为<60岁组(非老年组)77例,≥60岁组(老年组)102例。测定空腹血脂、血糖、CAT、SOD、还原型谷胱甘肽(GSH)、谷胱甘肽还原酶(GR)、谷胱甘肽过氧化物酶(GSH-Px)等,测量身高、体质量等指标。根据每例患者的冠状动脉造影结果,采用 Gensini 评分系统对每支血管病变程度进行定量评分。结果：老年组患者血浆 CAT、SOD、GSH、GR 和 GSH-Px 水平均低于非老年组患者(P <0.05~ P <0.01)。校正年龄因素后,血浆 CAT、SOD、GSH、GR 和 GSH-Px 水平与 Gensini 积分仍呈显著负相关关系(P <0.01)。多元线性回归分析显示,GSH-Px 和 CAT 对 Gensini积分的影响作用更大(P <0.01)。结论：随着年龄增长,血浆 CAT、SOD、GSH、GR 和 GSH-Px 明显降低,与冠脉病变程度具有一定的负相关性,且 CAT 和 GSH-Px 对冠脉病变的影响作用更大。